Domas of different anatomic locations biologically different?
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What accounts for low rate of distant metastasis? safe women take viagra Chordomas are thought to arise from notochordal cells lodged inside the vertebrae, which are derived from the same population of cells that forms the nucleus pulposus of the intervertebral disc.
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 why, then, do chordomas arise from within the bone and not the intervertebral disc? cheap generic viagra in canada Is there some factor in the bone that causes notochordal cells to proliferate? Chordomas are comprised of multiple morphologically distinct cell types. viagra for the brain pill  are all these cell types neoplastic or is one cell type responsible for neoplasticity?
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Why do chordomas characteristically form intralesional fibrous septae and lobules?  why do ferrets have a higher incidence of chordomas than other animals?
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 is there something about the brachyury gene in ferrets that contributes to chordoma susceptibility? Are chordomas generally hypoxic? Why are chordomas highly radio-resistant? age should men use viagra Why are chordomas resistant to cytotoxic agents? natural herbs vs viagra Do systemic drugs reach chordomas? Are there are any tumor-specific rearrangements in chordomas?
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Are there any clear-cut diagnostic criteria for differentiating between chondroid chordomas and chondrosarcomas?
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Is the loss of 3p an early event in chordoma genesis? natural herbs vs viagra Are tumor suppressor genes or mismatch repair genes (located at 1p31 and 3p14) and oncogenes (located in 7q36) involved in chordoma genesis?
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Is there a functional relationship in chordomas between galectin-3 and laminin, perhaps in modulation cell adhesion and motility?
Does e-cadherin play a role in chordoma tumor cell adhesion?
What is the significance of cell cycle aberrations in chordoma?
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Given that egfr is frequently expressed and phosphorylated in chordomas, could treatment with egfr inhibitors effective? Are egfr / pdgfrb heterodimers responsible for imatinib resistance?
â histology nuclear pleomorphism was detected in 26 of 65 sbcs and 24 of 29 nsbcs.
 intralesional fibrous septae were observed in 79 of 122 chordomas. .
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